@sajib056 , from your post it appears that :
(a) you came in as F-1 in 2016 and therefore ( assuming this was your first entry into the USA ), your exempt status was completed on 12/31/2020. So 2021 you counted your "days present" towards SPT and became a resident for tax purposes for the year 2021.
(b) your spouse whom also entered the USA on a dependent visa ( F-2 ) in 2016 , also became a resident for tax purposes in 2021.
(c) So for 2021 tax year , you can either file as MFJ ( Married Filing Joint ) or MFS ( Married Filing Separate ). You cannot claim to be HoH ( Head of Household ) , even if your spouse lived separate from you for the last six months of the year unless you have a qualifying dependent -- you need qualifying dependent AND considered unmarried.
I hope I am understanding your case properly --- what are you trying to achieve ?
pk