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What type of business? What type of loss? If you have a sole-proprietorship,you will have a loss if expenses are more than your income.
Fill out Schedule C.   Enter your gross income and expenses.  Turbo Tax will calculate the gain or loss.  
Where to enter schedule C
https://ttlc.intuit.com/community/entering-importing/help/where-do-i-enter-schedule-c/00/26092
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