Can we file do a married filing jointly return using turbo tax when my wife is on H1B and is a resident alien for tax purposes, I am on F1 and a non-resident alien?

[LinaJ2020]

Yes, you can. 

If your wife is on H-1B and a US resident, she can make an election to claim you, the nonresident, to be a resident and file jointly together.  For instructions, click here: Nonresident to resident

As your spouse does not have an SSN or ITIN, you would need to apply one for her.  Please see  ITIN

Per IRS, you cannot e-file a tax return that does not include an SSN or ITIN.  You can still use the TurboTax program to prepare your tax return and required tax forms.  Print and attach them to the Form W-7 with the required documentation and submit all the papers to the IRS by mail. 

Here is what you would need to do in the TurboTax program, 

-As you enter the information, leave the spouse's SSN space blank

-After entering all your information, print out returns and required forms, then write APPLIED in the SSN space on the forms.

[mohar1406]

Thank you for your prompt response. My spouse does have a SSN. So we should be able to e-file everything right? 

[LinaJ2020]

Yes.  You should.  Just enter her SSN number in the appropriate space and e-file the tax return.