The severance is subject to withholding just like wages, the employer can either use an aggregate method (calculating the withholding as if that was your regular wages for the whole year) or using a flat 22%. The aggregate method should be self-adjusting and not leave you short. If the employer uses the flat 22% method, then you need to look at your overall income. If you will be married filing jointly, you will pay 22% if your income after deductions is less than $206,000; 24% if you are between $206,000 and $394,000, 32% up to $500,000, and eventually up to 37%. So depending on your total expected income, 22% might be just right, or you might have to add extra to your payments.