you need to provide more details for anyone to help...
are you talking about 1099-INT Box 8 or 1099-DIV Box 12?
What do you mean by "whole other number" - is it close but off by a small adjustment, or just totally missing the 1099 amount?
If 1099-INT do you have any premium or accrued interest adjustments?
If 1099-DIV double-check the state assignments in the interview screens following the screen with the box amounts, are split correctly, and the 1099-DIV is not flagged for "needs review" when you look at the list of your 1099s.
If you are seeing strange numbers from a 1099 it's worth trying to re-input as a fresh 1099 especially if imported.