Yes, the gain is excludable (up to $250,000). You do have to pay tax on the depreciation recapture portion.
There are two different places to enter the sale. I find the interview goes smoother if you enter it as a home sale, rather than sale of rental.
"Depreciation recapture" is required whether you actually claimed depreciation, while you rented it out, or didn't claim it. If you didn't claim it, you (or she) can file an amended 2018 return to claim it now.