I am disabled so I will not be buying another home in the future. The house I sold is the last home I will own.
Yes, If you owned and lived in your home for two of the five years before the sale, then up to $250,000 of capital gain is tax-free. If you are married and file a joint return, the tax-free amount doubles to $500,000. The law lets you "exclude" this otherwise taxable profit from your taxable income.
Please read this TurboTax article for more information:
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