There are 4 concepts here we have to cover.
You can include interest on acquisition debt. Acquisition debt is debt used to buy, build, or substantially improve your home.
Repairs are not improvements. Repairs maintain the property in as-is or as-was condition. Repairs are the responsibility of every homeowner and you don't get special tax breaks or consideration for repairs.
Improvements add value to the home, or extend the life of the home or one of its systems, like the roof system or the plumbing system. For example, fixing a leaky toilet or repairing a hole in the roof is not an improvement. Changing out an old toilet for a new water saving toilet, or replacing a roof, is an improvement.
So in your question, "major repair" is unclear. Repairs can't be included in the interest deduction, but improvements can be included. It depends on what work you will actually be doing.
Lastly, you have to incur the debt (take the loan) in a reasonably close time to the improvement so that you can reasonably be said to use the money for the improvement. There's no clear definition of the time involved, but other sections of the tax code suggest that if you take out the loan more than 90 days after the improvement or more that 2 years before the improvement, you can't count the interest as acquisition debt even if you used the money to pay for the improvement, since they are too far apart in time to make that link.
Where this makes a real difference is with a second mortgage or fixed equity loan. If you take a cash out refinance, and then 5 years later you need to replace the roof, it's too long ago to say that part of the cash out was used for the roof and should count as deductible interest. With a line of credit, you only borrow the money when you draw on the credit line, so if you draw on the line to pay for the improvements, that makes the link clear.
So the bottom line answer is yes, probably, but it depends on what you are calling a major repair.
