Would like to purchase a home. Where can we withdraw the money to pay cash with the least amount of tax penalty? IRA's, Roth IRA's, stocks. Each would cover the purchase

[lifeordeath489-]

Any combination of the above accounts would cover this purchase with enough for us to live thru retirement. We are age 67

[Opus 17]

There's no right answer for you, it depends on your asset mix, your goals, your health, and other aspects of financial planning.  

In general, if you withdraw from a Roth IRA, it is tax-free, as long as the Roth IRA was established 5 years ago or longer.  Withdrawals from a traditional IRA are subject to regular income tax (12%, 22%, or higher).  If you sell other investments that are not inside tax-protected accounts, you pay capital gains tax only on the gain, at a rate of 0% or 15% (lower than the tax on an IRA).  

But you also need to think about the mix of assets you have, and what mix you want to have after the purchase.  There are financial reasons to have a mix of assets.  There are different reasons to want to prefer keeping money in a traditional IRA (that would favor selling other investments first).  There are also reasons you might want to prefer to keep a Roth IRA (and preferentially sell or withdraw other assets first).

You may want to discuss with a financial planner.

[fanfare]

If you can buy your home with sale of stocks in a regular account, not tax-deferred. that have a loss, you can have your home and a deduction too.

@lifeordeath489-