@erwinturner wrote:
Our effective tax rate on regular income last year was ~12%. I was planning to send in $55,000 to the IRS after closing next week. Does that sound reasonable?
You will probably owe more than that.
You said "effective" tax rate, which seems to indicate you were in the 22% tax bracket. That mean the entire $400,000 will be taxed at 15%, which is $60,000.
But then you will also owe the Net Investment Income Tax. Depending on the rest of your income, that could be an additional $10,000.
https://www.irs.gov/newsroom/questions-and-answers-on-the-net-investment-income-tax
That 'extra' income could also have other negative consequences, such as reducing some credits or deductions.
You could create a 'mock' tax return and enter your estimated 2025 income, including the sale of the second home, to get a better idea for the results.