1099-s

To enter the sale of your main home and claim the exclusion in TurboTax Online:

1. If you don’t see 2022 TAXES in the left pane, select the dropdown to the right of Income & Expenses on the Hi, let’s keep working on your taxes! page and then select Let’s get started, Pick up where you left off, or Review/Edit. 
   • Otherwise, in the left pane, select Federal, then Wages & Income (This is labelled Income & Expenses in TurboTax Self-Employed)
2. Scroll down and select the Show more dropdown to the right of Less Common Income
3. Select  Start or Revisit to the right of Sale of Home (gain or loss)
4. On the  Sale of Your Main Home page, read the information in the Click here to see if you have to report the sale link to the right of Did you sell or have your home foreclosed in 2022?  This will help you determine whether or not you need to report your home's sale.      If you do, select Yes
5. Enter all relevant information on the ensuing pages
6. Be sure to answer correctly on the Time You Lived In Your Home page.  This and subsequent pages determine whether you qualify for the exclusion.    
7. When you're done with inputting this part of the interview, the Exclusion of Gain screen will tell you whether your gain has been excluded

You'll need to know:

• The date you sold your home, and the selling price of your home.  These can be found on your closing statement
• The date you bought your home and the purchase price.  This, too, can be found on your closing statement
• The cost of any major improvements you made, so the program can deduct them for you

@tanlongpham 

@tanlongpham , while agreeing with the  good explanation provided by @KrisD15 , just would like  clarify things a bit more on this depreciation  and its effects:

(a) for a residential rental property  ( no matter how acquired), you are allowed to "book" a depreciation amount based on the value of the depreciable portion of the asset  over a period of 27.5 years.  The value of the building  and its contents each may have a different class life.  The land underneath the house is not depreciable asset.

(b) Whether you recognize the allowable depreciation or not  ( it generally  lowers your tax on the rental income as negative amount ), the  yearly and allowable depreciation  accumulates --- this is called  accumulated depreciation of the property.

(c) When you sell the property and come back to your books :

The gain/ Loss on the property is based on difference between  Proceeds of the Sale  and  Adjusted Basis.

Adjusted Basis is the sum of   Acquisition  Price + plus Cost of Improvements over the years LESS Accumulated Depreciation.   Thus Depreciation lowers your basis.

Proceeds of the Sale is Sales Price LESS Sales Expenses  ( such a  RealEstate Commission, Transfer Taxes , Sales Prep Expenses etc. ).

When you have a Gain, the part of the Gain that is Equal to  Accumulated Depreciation is treated as Ordinary Gain  -- normal tax rate ( marginal rate ).  The rest of the Gain is given tax preferred treatment  -- Capital Gain Tax rate  --- anywhere between  zero and 28%.

Does this  explain your situation ?

Is there more I can do for you ?