No.
There is an exclusion of $250,000 ($500,000 for married) on the capital gains of your primary residence. You must have lived in the home for 2 of the last 5 years.
Here is how you enter in TurboTax:
In Income &
Expenses
Scroll to Less
Common Income, click show more
Click Sale of
Home (gain or loss) and start
Check "yes" you
sold your home
Home sale exclusion: Home Sale
Exclusion