Yes, TurboTax can help with a self-employed business with our TurboTax Self-employed (online)
https://turbotax.intuit.com/personal-taxes/online/self-employed.jsp
or TurboTax Home & Business (download/CD).
https://turbotax.intuit.com/personal-taxes/cd-download/home-and-business.jsp
Both of those programs can help generate 1099s.
If the business is a corporation or partnership, we have TurboTax Business (download).
https://turbotax.intuit.com/small-business-taxes/
If you have other questions about this, ask in the comment section below.