There currently is an issue with some Underpayment of Estimated Tax Penalty Forms (Form 2210) not being calculated correctly.
If this is the issue that is preventing you from being able to e-file your return, please see a sign up link in this Help Article where you will be notified of updates to this issue: Why is My Form 2210 Not Calculating Lines 18-26 Correctly?
Also see this for additional information on e-filing issues: E-File Issues
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