You can remove your spouse from your return if it has not yet been submitted to IRS electronically or paper filed in the mail to IRS. Since you were still married at the end of the year, then you will also have to change your filing status which will change some of your tax credits and deductions. You would generally change it from married filing joint to married filing separate.
If you do so, you are obligated to advise her that you removed her from the return so she does not think her filing obligation has been satisfied.
If you are married and file a separate return, you generally report only your own income, deductions, and credits. Generally, you are responsible only for the tax on your own income. Different rules apply to people in community property states; see Pub. 555.