If you realized a capital gain on the sale of your real estate, you would be wise to make estimated tax payments. I recommend you pay 100% of the capital gain with the first quarter payment so that the payment is for the same quarter that the gain occurred. The first quarter due date is due April 15. The remaining estimated tax due dates are June 15, September 15, and January 18.
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Yes - You can do that. DavidD66's thinking was to make a larger payment in the quarter you receive the income. But you certainly can spread the estimated payments throughout the year. It will all get reconciled on your 2021 return.