Yes, the amount from Form 1099-S Box 2 should be Gross Selling Price. This may be adjusted if you received payments other than cash. In most cases, TurboTax provides a separate entry field for selling expenses, or provides guidance on adjusting the proceeds for your expenses.
If you are reporting the sale of your primary residence, you should not adjust this amount for Selling Expenses paid from the gross proceeds. Instead, enter the amount of Selling Expenses in the box provided on the Sales Information page (see screenshot #1 below - click to enlarge). See the blue links on that page for more help.
If this was the sale of a Second Home (entered under Investment Sales), check the box for "I paid sales expenses not reported..." This opens a drop-down box where you may enter your selling expenses (screenshot #2).
If this was the sale of Rental Property, enter the gross proceeds from Form 1099-S in the Asset Sales Price box and your selling expenses as Asset Sales Expenses (screenshot #3).
For any other type of sale reported on Form 1099-S, look for blue links ("Learn More") for help on how to report both the sales proceeds and the selling expenses.
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