Error 2 on Turbotax Business desktop

• Try turning off all anti-virus software, which could be blocking transmission.
• Change Internet security settings from Medium-High to Medium
• Make sure you're running TurboTax (and saving tax files) on your C drive

Here's more info on Troubleshooting TurboTax Desktop Issues. 

@cutwo-comcast-ne 

Having files on c: drive was the solution for me.  This is a bad error message that needs to be fixed.

Your answer has nothing to do with the error 2.

My solution - decrease the .pdf file size. Your server might have some limits on accepting files. I decreased it to standard 5 MB and it worked. 

Thank you for the tip about the attached form 8453 PDF file size. Decreasing the size did the trick. Much appreciated. -ds-

Likewise, once I re-pdfed the file to a smaller size and it transmitted. Thanks for the tip!