Please see this TurboTax FAQ for troubleshooting Tips on how to resolve this issue for TurboTax Cd/Download which explains to close all programs except TurboTax, including virus protection, download accelerators, and any other programs running in the background:
https://ttlc.intuit.com/community/e-file/help/what-if-transmit-returns-doesn-t-work/00/25805
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