The IRS uses a long list of reject codes that cover a number of possible reasons for the rejection. When you use TurboTax to prepare your return, we'll check for common errors before you file. But if your e-file is rejected, we'll tell you exactly why, and give you the steps to correct it. You'll be able to resubmit your corrected return, and we'll tell you when it's accepted by the IRS.
Please read this TurboTax article for more details.