You can only deduct expenses incurred for earning the income reported on the Form 1099-NEC as self-employment income. You will report this income and any related expenses on Schedule C. After entering the Form 1099-NEC, TurboTax will walk you through entering any expenses you incurred to earn that money.
Any expenses related to earning the income reported on the W-2 are not deductible for federal purposes. However, there are a few states that allow a deduction for these expenses on the state tax return. See this TurboTax Help article for more details: Can employees deduct any job-related expenses?
For more information regarding self-employment income, check out these TurboTax Help Articles:
What self-employed expenses can I deduct?
Thanks. That's pretty much what I thought, I'm just not sure about the items that overlap each other. For example, lap top, monitors etc that were purchased but used for both? Also, if the 1099 job is remote, can travel expenses (train) to go to meetings be deducted?