It depends. If the program isn't forcing it on you, you don't need to file.
The form 2210 is used to see if you need to pay a penalty or to request a waiver. You could have a refund and still owe a penalty for not paying taxes early enough in the year. Generally, if you owe less than $1,000, it isn't necessary.
See Topic no. 306, Penalty for underpayment of estimated tax