Should I buy Self Employed or Home & Business if I want to file returns for multiple people? I have a sole proprietorship and she'll file a standard personal return.

If you are needing to file multiple tax returns then you should be purchasing one of the TurboTax desktop CD/Download editions where you can complete as many tax returns as needed without further cost after the initial purchase.

Go to this website for the TurboTax desktop CD/Download editions - https://turbotax.intuit.com/personal-taxes/cd-download/

As a sole proprietor that reports their income and expenses on a Schedule C, that schedule is included with the  personal tax return, Form 1040.