No. A spouse is never a dependent. File a joint return. You do not say what kind of disability she gets. If it is Social Security disability, you need to enter her SSA1099. If it is some other kind of disability, it may or may not be taxable, but enter the tax document and let the software follow the rules.
Married Filing Jointly is usually better, even if one spouse had little or no income. When you file a joint return, you and your spouse will get the married filing jointly standard deduction of $29,200 (+ $1550 for each spouse 65 or older) for 2024. You are eligible for more credits including education credits, earned income credit, child and dependent care credit, and a larger income limit to receive the child tax credit.