Web Payment directly with the IRS
There isn't really anything to "file" if you use the IRS Direct Pay website....but you do need to indicate it is a 2021 estimated payment when you pay.
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Direct Debit from your bank account if you know your routing and checking account numbers:
https://www.irs.gov/payments/direct-pay
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or...Pay with a Credit or Debit Card:
https://www.irs.gov/payments/pay-your-taxes-by-debit-or-credit-card