Your 2021 federal refund would not impact your 2022 tax filing, unless you had your refund applied to 2022's taxes. In that case, you could still file your 2022 tax return but the IRS may not give you credit for the refund if they haven't processed it yet. In that case, they would just send it to you when it does get processed. So you can go ahead and file your 2022 tax return.