You may itemize your deduction, or take the Standard Deduction, whether you file Single or Head Of Household.
Neither of the filing statuses will affect your ability to itemize or take the standard deduction. Head of Household has a higher Standard Deduction, $18,350, than the Single filing status of $12,200.
There are various rules for claiming the Head of Household filing status:
To be "considered unmarried" for the tax year you must file a separate tax return you must:
You can learn more about the Head of Household filing status here. You can learn more about itemizing deductions here.