I'm not sure what your concern is, but here is the process to enter a 1099-S. There are two areas that it may apply to.
It could be for the sale of your primary residence.
Go to Wages & Income
Scroll all the way down to Less Common Income
Select Sale of Home (gain or loss)
Continue through the interview, and post the information from the 1099-S
For the sale of anything else. (Land, second home personal items)
Let's import your tax info = Enter a different way at bottom of page
Select the Other block = Continue
Follow the interview.
Im using home & business. It never gives me the option to add investments at the bottom of the page, keeps going back to 1099B
I should also note that the 1099S is for sale of timber.
In the Home & Business version of TurboTax Desktop, you would enter the 1099-S from the timber sale using these steps:
The timber sale will be recorded in your tax return. Here is more information from Timber Tax.