If you received form 1099-S for the sale of your primary home, you need to report the sale on your income tax return because the IRS will be matching the 1099-S form to your tax return. If it's not on your tax return, it may delay the processing of your return.
You may also need to report the sale of your primary home to see if you have a gain. If you have a gain, you'll have to pay income taxes.
Please see, Is the money I made from a home sale taxable?