It depends. If you have an area of the home that is no larger than 300 square feet that you use exclusively and regularly for business, the simplified method may be more advantageous in some respects. While the deduction is limited to no more than $1500 for the year, it does not require an additional form and also will make for easier calculations when you sell your home, because you will not have to account for such things as depreciation recapture, for example. However, the regular method may lead to a larger overall deduction, especially if you are in an area of higher property value or have a larger office than 300 square feet.
Click on this link for an IRS consideration of this topic: Home Office Deduction | Internal Revenue Service