No, you don’t need to input data from Form 3921 on your return.
Form 3921 is an informational form only. You typically won’t enter information from it on your tax return unless you actually sold the stock, or if you might be subject to alternative minimum tax (AMT).
When you receive Form 3921, that means that your employer transferred stock to you because you exercised an incentive stock option (ISO). Because this is a statutory stock option, there are generally no tax consequences for having exercised the option.