You can claim a casualty loss deduction using Form 4684 for Ponzi scheme losses; however, the issues of when the qualifying theft occurred and the relevant dollar amounts can be quite complex.
The TurboTax in-program guidance at a Learn More link in the Casualty Loss section states:
"We're sorry to hear about this loss. Unfortunately, this type of loss can be particularly complicated for tax purposes, and in many situations the tax treatment depends on factual determinations best handled by an attorney. TurboTax does not support tax losses from investment fraud. We recommend consulting a tax professional if you've experienced this situation."
The IRS Instructions for Form 4684 explain how to report a theft loss deduction for a Ponzi-type investment scheme.
The IRS provides two items of guidance to help taxpayers who are victims of losses from Ponzi-type investment schemes:
See this IRS webpage for more information for taxpayers affected by Ponzi scheme losses.