No.
If you are a regular W-2 employee, you are no longer (effective 2018) allowed to deduct job expenses, including a home office. Even when you were allowed to, it was only an itemized deduction subject to the 2% of AGI threshold.
The (up to) $250 educator expense adjustment to income ("above the line" deduction) still applies. See https://www.irs.gov/newsroom/what-teachers-should-know-about-deducting-out-of-pocket-classroom-expenses#:~:text=Fortunately%2C%20eligible%20educators%20may%20be,and%20file%20a%20joint%20return.
As an educator (W-2 Employee) you can only claim education related expenses up to $250 and only under the Deductions & Credits tab in the Job Related Expenses section specifically for teachers and educators. It's an itemized deduction on SCH A subject to limits. So unless you have an exhorbent amount of other deductions so that your total deductions exceed your standard deduction, it won't make any difference to your tax liability.