Yes, you can file multiple states with TurboTax. The general rule is if you are a resident in a state with income tax, you are taxed on all income. If you are a nonresident, you only pay tax on the income from that state. If you moved during the year, you file a Part Year return for each state you lived in and apply the resident/nonresident income. TurboTax asks the questions and can guide you through the process- and you can always get help if needed!