It depends whether your 1099-Misc was received in connection with your business or whether the work you performed was non-business related, e.g., a type of hobby. However, because you used the term "artist grant" in your post, we need some additional information before advising how to handle this income and expense.
The IRS has stated that grants are taxable, but they may not taxable provided the following conditions are met:
Does any of the above apply to your situation? Additionally, does your work as an artist constitute a trade or business, e.g. do you do this work to earn a profit and do you offer your art services to others?
If your artist grant does not fall within the above IRS requirements, then the income is taxable. If your art work is your business, then you can deduct the $1,000 expense as a business expense on Schedule C, Profit or Loss From Business. You will need to use TurboTax Premium (online version) or TurboTax CD/download to enter expenses associated with self-employment.
If you need to report this income as self-employment income, then from Wages & Income, scroll down to Self-Employment (if you are using TurboTax CD/download, then scroll down to Business Items and select Business Income and Expenses (Sch C)). Enter your information on the screens as appropriate.
However, if your work was more like a hobby and not a business, your $1,000 expense would not be deductible. You would also have to report the total income you received--$1,500--on your return despite the fact that you had $1,000 in expenses. Hobby income is taxable income, but hobby expenses are not deductible.
In TurboTax, hobby income is entered in the Less Common Income section. If you are using TurboTax online, select Wages & Income (left margin), scroll down the screen to Less Common Income. You might have to click on the Show more drop-down arrow to reveal all of the options. Click start across from Miscellaneous Income and enter your information on the subsequent screens.
If you are using TurboTax CD/download, the process is essentially the same. Keep in mind that your expenses associated with your hobby income are not deductible. In other words, you cannot use those expenses to offset your hobby income.