My wife received a W-2 for the year of 2022, but she didn't work. What are supposed to do with this?

You will want to contact the IRS immediately- it is likely that someone is using her social security number for work authorization.  See Identity Protection: Prevention, Detection and Victim Assistance and Contact My Local Office Internationally.

....Unless you can explain what the W-2 was for.

One year I received a W-2 form a company I had not worked for in over a year, and it was due to some special employee fund/stock distributions that occurred in the next calendar year, long after I left.