Is there a decent sized deduction we can use to minimize what we owe, using wife's small business and some sort of retirement account?

Wife and I have a very large tax bill according to TT and I'm hoping to minimize the pain.  Wife has a small business as a psychologist, and she made a profit last year.  Is there a retirement vehicle she could take advantage of this late that would give us a deduction (and the largest one possible?!) Thanks in advance.