I have about a dozen 1099-mis to report; can I aggregate the total as one line item on my return, or do I need to break out each form with the full details of the payee?

Yes you can just enter the total income you received.  Or do you mean for 1099Misc you gave out?  Same answer.  Just enter the total in Contract Labor Schedule C line 11.

Thanks -- for clarification, the 1099-Misc were received by my wife and myself for various consulting jobs over the last year.