Do you have to use annualized income method to calculate on penalty? Turbo Tax will not let me go back to regular method?

Have you tried deleting the 2210 form?  See the following on how to delete a form, choose the instructions for the version you are using.

Here's how to delete forms in TurboTax Online:

1.     Open your return, if it's not already open.

2.     In the lower left click on Tax Tools.

3.     Select   Delete a form.

4.     Click Delete next to the form or schedule and follow the instructions to remove the form/schedule.