How do I enter expenses related to handling the closure of the physical assets of an estate?

Are you preparing the tax return for the estate? If so, estate expenses are reported in the Deductions section of TurboTax Business for an estate. If none of the specific categories seem appropriate, enter the costs under Other Deductions.

If these were closing costs involving the sale of estate assets, however, those costs would be part of the sale transaction. Sales of Assets are reported under the Income section of Federal Taxes, under the appropriate topic.