The program keeps updating every time I open it. I am ready to file, but am afraid something will change after I've filed. When is it safe to file?

Always print a copy of your completed tax return for your records, and review it carefully before e-Filing.
You will need it if you are audited by the IRS, to contact the IRS, or to amend if a TurboTax update changes your return or for any other reason,

AND, to find your AGI next year.

@kuhnjohnb