My W2 was amended to include 2 amounts in box 14, PASUI and PA LST. We already filed federal and state without these numbers, should we file an amendment?

The PA SUI is deductible as an itemized deduction on the federal return.  If you took the standard deduction, likely will not make a difference on your federal return.  If you itemized and the PA SUI is large, it may reduce your taxes, depends on a dozen other factors.  You are not required to file an amendment if you have reported all your income.