Can I attempt to settle with the IRS through TurboTax or would I need to get ahold of my local IRS office to talk about an Offer in Compromise

TurboTax cannot help with an offer in compromise.  The IRS does not share information about your tax returns with TurboTax, nor can TT intercede with the IRS on your behalf.  You might want to find a good local tax professional to help you.