If you have deductions such as home-related deductions, education expenses, medical bills, or other itemized deductions, you will need TurboTax Deluxe or higher for those things. So if you need to itemize deductions on Schedule A and file a 1040 long form, you will need Deluxe or higher for that.
You can do the Tell us about you and it will recommend the TurboTax product that's right for you.