What product are you using? Are you using desktop software on a Mac by any chance?
Have you tried a manual update?
Unless someone else has a suggestion in the forum on Friday, you may end up having to phone TurboTax Support. But they would likely want you to try a manual update first to see if that makes any difference. I don't know what product (personal or business) you are using, so I'll give both links, and also a FAQ on phoning TurboTax Support.
Manual update for desktop personal editions
Manual update for Business edition.
TurboTax Support hours are 5AM-9PM Pacific (8AM-12 Midnight Eastern), 7 days/week
FAQ: What is the TurboTax phone number?
https://ttlc.intuit.com/community/using-turbotax/help/what-is-the-turbotax-phone-number/00/25632
ADDENDUM:
NOTE: The manual update doesn't update any state program. If it turns out that a state program is causing your update problem, also see if the following helps:
FAQ: How do I get the latest update for my downloaded state program?
Otherwise, phone TurboTax Support as mentioned above.
I am getting this same failed validation error using Turbo Tax premier. I tried to transmit only the Federal Return and it won't work. Didn't even try to transmit PA return yet. I have done a manual update and the information provided by customer service was of no help. This is frustrating.