All versions of the desktop software will go through the Schedule C interview - there is more guidance in the higher level versions, but you can enter both Schedule C income and expenses in any version. The Home & Business has the most guidance included for preparing a Schedule C, but Deluxe also has the interview with many fewer help screens.
There is no Business tab up top in Deluxe, but you can get to the interview under the Federal Taxes tab and then within the Wages & Income section. See below.