No, there is not an exception to the 10% early withdrawal penalty if the withdrawal is from a 401(k) account and is used for a home purchase, first home or not. The exception is only if the withdrawal is from an IRA, for a first time home purchase and then only $10,000 is eligible for the penalty exception.
See this IRS Tax Topic for Additional Tax on Early Distributions from Retirement Plans Other than IRAs - https://www.irs.gov/taxtopics/tc558
See this IRS Tax Topic for Additional Tax on Early Distributions from Traditional and Roth IRAs - https://www.irs.gov/taxtopics/tc557
