That depends. If this was never a rental property, but not your main home any time during the last five years, you could report it as the Sale of a Second Home. Any taxable gains would be based on the difference between your Cost Basis and the Sale Proceeds.
If it was your main home any time in the last five years, you may qualify for the Home Sale Exclusion and not need to report the sale in your tax return. The fact that you re-invested the proceeds into another property no longer is applicable in US taxes.
@ss88
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