If you take the Standard Deduction you can also take 600 max for Charity. So the Standard Deduction + 600 can give you a bigger deduction than your itemized deductions.
See this FAQ for the Itemized vs Standard Deduction confusion. It's for last year 2020 returns but still applies for 2021. And 2021 can be 300 single or 600 married.
https://ttlc.intuit.com/community/charitable-donations-deductions/help/standard-vs-itemized-deductio...
For 2021 the standard deduction amounts are:
Single 12,550 + 1,700 for 65 and over or blind (14,250)
HOH 18,800 + 1,700 for 65 and over or blind
Joint 25,100 + 1,350 for each 65 and over or blind
Married filing Separate 12,550 + 1,350 for 65 and over or blind
