If you work at many job sites and don't have a permanent job site (or one lasting more than a year), and you use your home for your administrative functions (billing, appointments, making calls, etc.) then your home can qualify as your main place of work. See page 3-5 here. https://www.irs.gov/pub/irs-pdf/p587.pdf
Then, you also have to meet the regular and exclusive rules to take the home office deduction.
